Genomics in Precision Oncology Xchange
Europe, Munich
June 28, 2022
Welcome to hubXchange’s European Genomics in Precision Oncology 2022, bringing together executives from pharma and biotech to address and find solutions to the key issues faced in genomics-led oncology precision medicine strategies.
Discussion topics will cover Cancer Genomics, Translational Bioinformatics, Data Quality & Access, Genomics Informed Clinical Decisions and Precision Oncology.
Take advantage of this unique highly interactive meeting format designed for maximum engagement, collaboration and networking with your peers.
This will be an In-Person meeting with a hybrid option to join virtually.
Venue Details: Hilton City Munich, Rosenheimer Strasse 15, Munich
Cancer Genomics
Opening Address & Keynote:
Getting de-centralized testing into routine clinical oncology using high-performance genetic multiplexing
- The need for accessible, easy-to-use technology that deploys seamlessly across labs in the liquid biopsy space
- Assay standardization democratizes this tool for the absolute quantification of ctDNA, supporting the practical clinical development of biomarkers
- Fast turnaround times, higher multiplexing, and increased sensitivity – all without the need for outsourcing of samples – can bring uncompromised real-time oncology diagnostics and monitoring to patients
Co-Founder, Stilla Technologies
With 10 year experience in the Life Science sector, Clément Gay co-founded Stilla Technologies. He is directing business & corporate development activities with the goal of establishing partnerships with Biopharmas & CROs to develop content (CDx, IVD kits etc.)on the naica digital PCR system . Clément graduated from HEC Paris, with a Master Degree in Business & Entrepreneurship.
Better informing treatment options
- How to enable oncologists to get faster decisions using molecular testing
- How do we better support the practical clinical development of biomarkers
- Identifying and measuring personalized mutations in the patient monitoring setting
Co-Founder, Stilla Technologies
With 10 year experience in the Life Science sector, Clément Gay co-founded Stilla Technologies. He is directing business & corporate development activities with the goal of establishing partnerships with Biopharmas & CROs to develop content (CDx, IVD kits etc.)on the naica digital PCR system . Clément graduated from HEC Paris, with a Master Degree in Business & Entrepreneurship.
Spotlight Presentation: Unlocking the complexity of tumor heterogeneity with multiplex imaging and spatial phenomics.
- Why spatial relationships are important in tumor biology
- Examine specific cell clustering, dispersion, and co-localization
- Identify immune rich and excluded regions and better inform your trial design.
- To better understand the biology within tissues with a quantitative summary of the regions and phenotypes present.
Senior Director Molecular and Computational Pathology, Ultivue
As a Senior Director, Molecular and Computational Pathology at UV Sotirios is responsible for establishing augmented pathology workflows and for implementing innovative data-driven QC methods. Sotirios is a board-certified MD, PhD anatomical pathologist with 10 years of experience in Translational Research, and Cancer Diagnostics. He also holds a Master´s degree in Web Science from the Dep. Of Mathematics, Aristotle University.
Sotirios started his career in 2011 at the Laboratory of Molecular Oncology in Thessaloniki, Greece where he laid the foundations of his expertise in translational science and molecular diagnostic techniques, studying the genotypic and phenotypic heterogeneity of the major cancer types.
Since 2014, he has been part of cross-disciplinary industry efforts to establish and validate novel diagnostic and translational pathology workflows, develop precision biomarker concepts, and commercialize oncology diagnostic devices such the MammaTyper® (BioNTech Dx) and the NEOLiquid assays (NEO New Oncology).
In 2018 Sotirios joined Definiens/Computational Pathology AstraZeneca, to build an integrated pathology informatics team with the goal to enable advanced tissue-informed decision-making in oncology drug development programs, by delivering state-of-the-art pathology data for the training and verification of machine learning algorithms.
4:10 – 4:40pm
Poster Session: Single-Cell DNAseq to Advance Oncology Research
- Unravel tumor heterogeneity, reconstruct phylogenetic trees, and discern early driver gene alterations
- Improve patient stratification distinguishing responders from non-responders
- Reveal therapy resistance mechanisms through course of treatment
- Monitor patients for minimal residual disease (MRD) with high sensitivity of single-cell analysis
- Identify better therapies and guide adaptive/rational combination therapies
Technical Application Liaison, Mission Bio
Simone Formisano is Technical Application Liaison at Mission Bio. He obtained his Master’s Degree in Biotechnology at Columbia University, New York City (United States). Before joining Mission Bio in 2022, Simone completed his Doctorate experimental work in cancer immunotherapy at
Ludwig Maximilian University of Munich. Afterward, he contributed to the clinical development of several therapies in solid oncology by joining Daiichi Sankyo as a Medical Science Liaison.
Translational Bioinformatics
Opening Address & Keynote:
Getting de-centralized testing into routine clinical oncology using high-performance genetic multiplexing
- The need for accessible, easy-to-use technology that deploys seamlessly across labs in the liquid biopsy space
- Assay standardization democratizes this tool for the absolute quantification of ctDNA, supporting the practical clinical development of biomarkers
- Fast turnaround times, higher multiplexing, and increased sensitivity – all without the need for outsourcing of samples – can bring uncompromised real-time oncology diagnostics and monitoring to patients
Co-Founder, Stilla Technologies
With 10 year experience in the Life Science sector, Clément Gay co-founded Stilla Technologies. He is directing business & corporate development activities with the goal of establishing partnerships with Biopharmas & CROs to develop content (CDx, IVD kits etc… )on the naica digital PCR system . Stilla Clément graduated from HEC Paris, with a Master Degree in Business & Entrepreneurship.
Networking Lunch
Spotlight Presentation: Unlocking the complexity of tumor heterogeneity with multiplex imaging and spatial
phenomics
- Why spatial relationships are important in tumor biology
- Examine specific cell clustering, dispersion, and co-localization
- Identify immune rich and excluded regions and better inform your trial design.
- To better understand the biology within tissues with a quantitative summary of the regions and phenotypes present.
Senior Director, Molecular and Computational Pathology, Ultivue
As a Senior Director, Molecular and Computational Pathology at UV Sotirios is responsible for establishing augmented pathology workflows and for implementing innovative data-driven QC methods. Sotirios is a board-certified MD, PhD anatomical pathologist with 10 years of experience in Translational Research, and Cancer Diagnostics. He also holds a Master´s degree in Web Science from the Dep. Of Mathematics, Aristotle University.
Sotirios started his career in 2011 at the Laboratory of Molecular Oncology in Thessaloniki, Greece where he laid the foundations of his expertise in translational science and molecular diagnostic techniques, studying the genotypic and phenotypic heterogeneity of the major cancer types.
Since 2014, he has been part of cross-disciplinary industry efforts to establish and validate novel diagnostic and translational pathology workflows, develop precision biomarker concepts, and commercialize oncology diagnostic devices such the MammaTyper® (BioNTech Dx) and the NEOLiquid assays (NEO New Oncology).
In 2018 Sotirios joined Definiens/Computational Pathology AstraZeneca, to build an integrated pathology informatics team with the goal to enable advanced tissue-informed decision-making in oncology drug development programs, by delivering state-of-the-art pathology data for the training and verification of machine learning algorithms.
Opportunities and challenges of using multi-omics data in precision medicine
- How do we best leverage different omics data modalities for biomarker discovery and patient stratification? What data modalities are the most informative, what are we missing?
- Share experiences in multi-omics data acquisition and data integration.
- Discuss the current landscape of AI/ML approaches to best leverage pre-clinical and clinical omics data for precision medicine
Associate Director & Senior Principal Scientist, Novartis
Slavica Dimitrieva works as an Associate Director & Senior Principal Scientist at the Novartis Institutes for BioMedical Research Oncology in Basel. She has over 10 years of bioinformatics experience working closely with biologists, clinicians, and scientists in academia, hospitals, and pharma, helping with deriving insights from large-scale biomedical data. At Novartis she co-leads the data science efforts in target identification. She is passionate about applying AI on multi-omics data for oncology drug discovery and precision medicine.
Slavica has a background in Computer Science and a PhD in Bioinformatics from the EPFL in Lausanne, Switzerland. After a postdoc at the Imperial College London, she worked as a Bioinformatics Scientist and Lecturer at the Functional Genomics Centre at ETH Zurich and University of Zurich, before joining Novartis. At Novartis her focus is on data-driven drug discovery from single cell and spatial omics .
Data Quality & Access
Opening Address & Keynote:
Getting de-centralized testing into routine clinical oncology using high-performance genetic multiplexing
- The need for accessible, easy-to-use technology that deploys seamlessly across labs in the liquid biopsy space
- Assay standardization democratizes this tool for the absolute quantification of ctDNA, supporting the practical clinical development of biomarkers
- Fast turnaround times, higher multiplexing, and increased sensitivity – all without the need for outsourcing of samples – can bring uncompromised real-time oncology diagnostics and monitoring to patients
Co-Founder, Stilla Technologies
With 10 year experience in the Life Science sector, Clément Gay co-founded Stilla Technologies. He is directing business & corporate development activities with the goal of establishing partnerships with Biopharmas & CROs to develop content (CDx, IVD kits etc.)on the naica digital PCR system . Clément graduated from HEC Paris, with a Master Degree in Business & Entrepreneurship.
9:05 – 10:05am
- Data sources and their integration for a seamless precision medicine approach
- Deriving actionable insights through omics data
- Genetic epidemiology
- Patient Privacy and information security
Medical Lead Ophthalmology, Novartis Pharma Switzerland
After completing his PhD at the ETH Zurich in Oncology using multi-omic approaches, Amit continued his interest in high throughput omics driven research by pursuing a PostDoc followed by a Group Leader role at the University of Zurich in Ophthalmic Genetics and Genomics. He joined Sophia Genetics as a NGS Scientist and is most recently working in Medical Affairs in Pharmaceutical industry. Throughout his career, Amit has focused on Oncology and Ophthalmology and is motivated about bringing novel diagnostics approaches to therapeutic decision making.
11:20am – 12:20pm
How NGS is moving the field towards comprehensive characterization:
The NeXT generation of tissue profiling and liquid biopsy
- Advances in NGS technologies to revolutionize personalized cancer vaccines, precision medicine and biomarker discovery.
- Existing challenges that must be addressed for both tissue profiling and liquid biopsy approaches.
- Various prevailing issues and strategies facing the field
Senior Field Application Scientist, Personalis
Maik Joined Personalis, Inc. as a Sr. Field Application Scientist (FAS) in 2020 with 20 years of research and field experiences in the area of molecular biology & immune-oncology, pharmacogenetics & genotyping, and clinical & molecular diagnostics. As an FAS he provides technical support for the Personalis immuno- and precision oncology portfolio. Maik has done his postdoctoral training at the Max-Planck-Institute for Molecular Genetics in Berlin (Germany) by leading a small team investigating the application of antibody arrays in the field of autoimmune diseases like rheumatoid arthritis. He received his doctoral degree for the molecular tumor genetics analysis of a T-cell oncogene from the Free University of Berlin, and his University diploma was completed by a thesis about transcript mapping on the human X- Chromosome within the Human Genome Project in Berlin.
Spotlight Presentation: Unlocking the complexity of tumor heterogeneity with multiplex imaging and spatial
phenomics.
- Why spatial relationships are important in tumor biology
- Examine specific cell clustering, dispersion, and co-localization
- Identify immune rich and excluded regions and better inform your trial design.
- To better understand the biology within tissues with a quantitative summary of the regions and phenotypes present.
Senior Director, Molecular and Computational Pathology, Ultivue
As a Senior Director, Molecular and Computational Pathology at UV Sotirios is responsible for establishing augmented pathology workflows and for implementing innovative data-driven QC methods. Sotirios is a board-certified MD, PhD anatomical pathologist with 10 years of experience in Translational Research, and Cancer Diagnostics. He also holds a Master´s degree in Web Science from the Dep. Of Mathematics, Aristotle University.
Sotirios started his career in 2011 at the Laboratory of Molecular Oncology in Thessaloniki, Greece where he laid the foundations of his expertise in translational science and molecular diagnostic techniques, studying the genotypic and phenotypic heterogeneity of the major cancer types.
Since 2014, he has been part of cross-disciplinary industry efforts to establish and validate novel diagnostic and translational pathology workflows, develop precision biomarker concepts, and commercialize oncology diagnostic devices such the MammaTyper® (BioNTech Dx) and the NEOLiquid assays (NEO New Oncology).
In 2018 Sotirios joined Definiens/Computational Pathology AstraZeneca, to build an integrated pathology informatics team with the goal to enable advanced tissue-informed decision-making in oncology drug development programs, by delivering state-of-the-art pathology data for the training and verification of machine learning algorithms.
Challenging privacy problems and elegant solutions that enable data sharing worldwide
Everybody wants to have the ability to share, buy and sell data in secure ways, among geographically distributed partners; but to accomplish this, we need to face legal implications, technical challenges and strategic hurdles. In this session, we will discuss the problems as well as promising technologies and strategic choices you can make to enable the sharing of data in ways that are not only secure but are also compliant with worldwide regulations. These solutions can open unprecedented possibilities to accelerate collaborations and create synergies across big pharma companies, biotech startups and university partners.
Global R&D Tech Head, Director of Innovation & Data Science, GlaxoSmithKline
Fausto has a double PhD (Information Technology and Computer Science), earning his second master’s and PhD at the University of California – Irvine. He has worked in multi-disciplinary teams and has over 20 years of experience in academia and industry. As a Physicist, Mathematician, Engineer, Computer Scientist, and HPC and Data Science expert, Fausto has worked on key projects at European and American government institutions and with key individuals, like Nobel Prize winner Michael J. Prather. After his time at NVIDIA corporation in Silicon Valley, Fausto worked at the IBM T J Watson Center in New York and now at GSK.
Genomics Informed Clinical Decisions
Opening Address & Keynote:
Getting de-centralized testing into routine clinical oncology using high-performance genetic multiplexing
- The need for accessible, easy-to-use technology that deploys seamlessly across labs in the liquid biopsy space
- Assay standardization democratizes this tool for the absolute quantification of ctDNA, supporting the practical clinical development of biomarkers
- Fast turnaround times, higher multiplexing, and increased sensitivity – all without the need for outsourcing of samples – can bring uncompromised real-time oncology diagnostics and monitoring to patients
Co-Founder, Stilla Technologies
With 10 year experience in the Life Science sector, Clément Gay co-founded Stilla Technologies. He is directing business & corporate development activities with the goal of establishing partnerships with Biopharmas & CROs to develop content (CDx, IVD kits etc.)on the naica digital PCR system . Clément graduated from HEC Paris, with a Master Degree in Business & Entrepreneurship.
9:05 – 10:05am
- We are striving for personalized medicine for decades using diagnostics and pharmaco-genetics. Omics are the next logical step and will be a center piece of future personalization for many patients/diseases
- OMIC’s alone may also not be the answer. Integration of standard Dx including expanded pathology, imaging and laboratory with OMICS is likely more successful
- OMICS may aid us in finding other, potentially easier to apply in routine clinical work, diagnostic parameters
- OMICS use in clinical trials will be facilitated by AI and quantum computing
Head of Medical Affairs Oncology Region Europe, Novartis
Following Graduation in Medicine at the Free University Berlin, Michael pursued a career in General, Cardiovascular and Surgical Oncology gaining an MD and an FRCS. He joined pharmaceutical industry more than 20 years ago and has since been in clinical development, project leadership, commercial and medical affairs roles at country, regional and global level. Throughout his clinical and industry career, Michael mainly covered specialty care areas, e.g. Oncology and Immunology. He also qualified as a Pharmaceutical Physician and as an MBA. Michael’s research interest and publications are in Oncology and Immunology, using AI to better direct treatment as well as in general aspects concerning Medical
and Clinical Affairs in the Industry
What omes matter for clinical biomarker discovery?
- What is the utility of scRNA, spatial transcriptomics, and high-throughput proteomics to biomarker developers at present?
- Are multi-omic biomarkers useful in clinical development?
- Are regulators and diagnostics developers ready for biomarkers based on anything other than DNA or low-throughput IHC?
Chief Discovery Officer, Genialis
Dr. Luka Ausec serves as Genialis’ Chief Discovery officer and directs internal R&D and external partner projects, with the common goal of advancing clinical development through rigorous application of data science. Dr. Ausec’s expertise in molecular and computational biology makes him uniquely adept at innovating solutions at this nexus. He believes a successful discovery process is built on clear communication and unwavering scientific integrity. Dr. Ausec oversees the implementation of ResponderID™, Genialis’ clinical biomarker discovery platform, which defines, models, and validates actionable biomarkers to accelerate translational research and clinical development. He earned his doctorate in molecular biology and biotechnology at the University of Ljubljana.
Spotlight Presentation: Unlocking the complexity of tumor heterogeneity with multiplex imaging and spatial
phenomics.
- Why spatial relationships are important in tumor biology
- Examine specific cell clustering, dispersion, and co-localization
- Identify immune rich and excluded regions and better inform your trial design.
- To better understand the biology within tissues with a quantitative summary of the regions and phenotypes present.
Senior Director Molecular and Computational Pathology, Ultivue
As a Senior Director, Molecular and Computational Pathology at UV Sotirios is responsible for establishing augmented pathology workflows and for implementing innovative data-driven QC methods. Sotirios is a board-certified MD, PhD anatomical pathologist with 10 years of experience in Translational Research, and Cancer Diagnostics. He also holds a Master´s degree in Web Science from the Dep. Of Mathematics, Aristotle University.
Sotirios started his career in 2011 at the Laboratory of Molecular Oncology in Thessaloniki, Greece where he laid the foundations of his expertise in translational science and molecular diagnostic techniques, studying the genotypic and phenotypic heterogeneity of the major cancer types.
Since 2014, he has been part of cross-disciplinary industry efforts to establish and validate novel diagnostic and translational pathology workflows, develop precision biomarker concepts, and commercialize oncology diagnostic devices such the MammaTyper® (BioNTech Dx) and the NEOLiquid assays (NEO New Oncology).
In 2018 Sotirios joined Definiens/Computational Pathology AstraZeneca, to build an integrated pathology informatics team with the goal to enable advanced tissue-informed decision-making in oncology drug development programs, by delivering state-of-the-art pathology data for the training and verification of machine learning algorithms.
Utilization of patient’s full tumour genetic information to create synthetic avatar models suitable for in vivo high-throughput drug screenings
- Can we use the full genetic landscape of the patient tumour (not only the actionable cancer driver genes) to guide clinical decisions?
- It is possible to create an avatar matching a patient’s genetic profile to develop ultra-tailored treatment recommendations.
- How many avatars need to be tested in pre-clinical settings to reliably identify the most optimal treatment for patients?
Chief Scientific Officer, Vivan Therapeutics
Nahuel Villegas is Chief Scientific Officer at Vivan Therapeutics. He has broad expertise modelling human tumorigenic processes in the fruit fly Drosophila melanogaster to study druggable conserved oncogenic targets. His work bridges basic and translational science, combining cancer genetic analysis with in vivo high-throughput drug discovery strategies aimed to find novel pharmacological anti-cancer cocktails for personalised therapy.
Selecting the right clinical genomic assays for the right questions
• How can we structure and formulate the right questions and select the right genomic assays?
• How can the generated genomic data be best utilized to inform clinical development decisions?
• What are the gaps to implementing emerging technologies such as single cell sequencing as clinical genomic assays?
Associate Director, Translational Oncology Lead
Pfizer
Koji is currently working at Pfizer as Associate Director, Translational Oncology Lead, Precision Medicine, Early Clinical Development WRDM. At Takeda, Koji lead a team of clinical biomarker scientists in executing and implementing biomarker readouts for dose and disease-indication selection, and patient stratification. In addition, Koji led a cross-functional team at Takeda in assessing emerging clinical technologies, specifically for single-cell sequencing.