Antibody Engineering Xchange EAST COAST 2018

Antibody Engineering

Titles and Bullets
9:00am – 10:00am

How to identify which is the best antibody platform to move forward with for lead identification?
  • What should be the most important selection criteria?
  • Deciding factors to weigh risk and value
  • Technology evolution, why and how?
  • What does the trajectory predict for the future?

Senior Director & Head
Antibody Discovery

10:30am – 11:30am

Selection of antibodies specific for multi-pass membrane proteins using mammalian virus display.
  • What are the biggest challenges to overcome to enable selection of antibodies specific for multi-pass membrane proteins?
  • What are the available technical solutions to these challenges?
  • How can recombinant virus display and VLPs be used to overcome these challenges?

Senior Vice President 
Research & Chief Scientific Officer

12:00pm – 13:00pm

How to validate conformation-specific antigen targets?
  • How do we know the selected antibodies bind a specific conformation such as a disease-specific form?
  • How can we differentiate normal and disease-related forms?
  • What methods can be used to validate protein conformations?

Chemical Engineering
Arizona State University

3:15pm – 4:15pm

Applications of antibody decoding through protein sequencing.
  • Applications of protein sequencing- is DNA sequencing the only choice?
  • Issues in antibody reproducibility and solutions. Is your mAb truly monoclonal?
  • Advances in MS sequencing; does Ile/Leu differentiation matter?
  • Future directions: MS sequencing in recombinant polyclonal antibodies.

Sales & Business Development
Rapid Novor

4:20pm – 5:20pm

How to apply NGS technology to speedup Ab lead discovery and increase lead Ab sequence diversity
  • Can NGS help your Ab discovery effort?
  • NGS platform: MiSeq or HiSeq, which one is more suitable for Ab library sequencing?
  • Sequencing Data analysis
  • How to pick Ab hits from NGS sequencing results?

Senior Director


Antibody Engineering Xchange | East Coast 2018